Also, IRT. Randomization and trial supply management (RTSM) is the process by which clinical trials are managed. It is a relatively new term that was coined to replace the interactive response system (IRS) to reflect the necessary interactions between the principal functions and the evolutions of technology and scale of functionality. RTSM allows for the management of trial subjects from enrollment to randomization, blinding, and unblinding. It is also used to manage supplies and drugs for clinical trials.